3 oz cooked grass-fed bison
1 100% whole-grain bun
1 tbsp organic ketchup
1 cup spinach salad
1 tbsp Italian vinaigrette
(Adds about 100 calories total - still less than a pre-made burger!)

Nutritional Information
272 calories
9 grams fat
0 grams trans fat
20 grams protein
4 grams fiber

Protein is the same, volume the same, but slashes artery clogging fat and calories. With my remaining 2 ingredients I'd either pile some veggies to the burger or add this side spinach salad:

Compare this nutritional information to that found in a frozen cheeseburger:
490 calories
26 grams fat
2.5 grams trans fat
24 grams protein
2 grams fiber